SPE is used to for many sample matrix types such as: water, beverages, serum, urine, milk, pharmaceuticals and food products. Some sample matrices are complex and have multiple interferences that make it difficult to analyze the compound of interest. You can use solid phase extraction to remove these interferences and to improve the quantification of the target compounds. SPE can also clean up the sample matrix, keeping your analytical instruments, such as mass spectrometers, free of reduced responses. SPE is also used as a fractionation tool that allows you to separate a large range of compounds from one sample, such as aliphatic and aromatic hydrocarbons from an extractable petroleum hydrocarbon sample. It allows for one sample to be analyzed for two things. SPE is effective for concentrating trace levels of compounds of interest onto the SPE cartridge by passing large volumes of sample matrix across the cartridge and then eluting the compounds of interest off of the SPE cartridge.